Research brief · Regenerative
ARA-290
EPO-derived peptide for non-erythropoietic tissue-protection research.
Class
Erythropoietin-derived 11-mer peptide
Half-life
~2 min (systemic)
Studied in
Neuropathic and tissue-protection research models.
What it is
ARA-290 (cibinetide) is an 11-amino-acid peptide derived from the EPO Helix B sequence. It activates the tissue-protective innate repair receptor without driving erythropoiesis, used in neuropathy and tissue-protection research.
Mechanism studied
Activates the innate repair receptor (IRR/βcR–EpoR heteromer) without erythropoiesis.
Research notes
- Separates EPO's tissue-protective signalling from haematopoietic action.
Before sourcing any material
- Confirm a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity).
- Check the stated peptide content per vial, not just the gross vial mass.
- Plan reconstitution volumes first so the vial size matches your protocol.
- Verify what is lawful in your jurisdiction — these are in-vitro research reagents, not medicines.