Research brief · Longevity
Epithalon
AEDG tetrapeptide used in telomere, pineal and cellular-senescence research.
Class
Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
Half-life
Very short (minutes)
Studied in
Telomere biology, pineal function and cellular-senescence research.
What it is
Epithalon (Epitalon) is a synthetic tetrapeptide based on the pineal-derived epithalamin sequence (Ala-Glu-Asp-Gly). It is studied as a research probe for telomerase activity, melatonin-axis modulation and cellular-senescence endpoints.
Mechanism studied
Proposed pineal/telomerase modulation and epigenetic regulation in cellular-senescence models.
Research notes
- Published work explores telomerase induction in somatic cell lines.
- Often paired with NAD+ and pinealon in longevity-research stacks.
Before sourcing any material
- Confirm a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity).
- Check the stated peptide content per vial, not just the gross vial mass.
- Plan reconstitution volumes first so the vial size matches your protocol.
- Verify what is lawful in your jurisdiction — these are in-vitro research reagents, not medicines.