Research brief · Longevity
FOXO4-DRI
Retro-inverso peptide tool compound for senolytic research.
Class
Retro-inverso peptide
Half-life
Short
Studied in
Senolytic research models.
What it is
FOXO4-DRI is a retro-inverso peptide designed to disrupt the FOXO4–p53 interaction selectively in senescent cells, used as a tool compound in senolytic research.
Mechanism studied
Disrupts FOXO4–p53 interaction in senescent cells.
Research notes
- A foundational reagent in peptide-based senolytic research.
Before sourcing any material
- Confirm a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity).
- Check the stated peptide content per vial, not just the gross vial mass.
- Plan reconstitution volumes first so the vial size matches your protocol.
- Verify what is lawful in your jurisdiction — these are in-vitro research reagents, not medicines.