Research brief · Growth Hormone
Ipamorelin
Selective GH secretagogue used in clean somatotropic axis research.
Class
Selective GH secretagogue (ghrelin mimetic)
Half-life
~2 h
Studied in
Somatotropic axis, recovery and sleep architecture studies.
What it is
Ipamorelin is a pentapeptide ghrelin mimetic that selectively activates GHS-R1a to elicit pulsatile growth hormone release while sparing cortisol and prolactin axes — a property that makes it a clean tool compound in somatotropic research.
Mechanism studied
Selective GHS-R1a agonist driving pulsatile GH release without cortisol/prolactin elevation.
Research notes
- Frequently combined with CJC-1295 (no DAC) to model GHRH + ghrelin synergy.
- Selectivity profile makes it suitable for endocrine specificity studies.
Before sourcing any material
- Confirm a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity).
- Check the stated peptide content per vial, not just the gross vial mass.
- Plan reconstitution volumes first so the vial size matches your protocol.
- Verify what is lawful in your jurisdiction — these are in-vitro research reagents, not medicines.