Research brief · Metabolic
Mazdutide
Oxyntomodulin-derived GLP-1/GCG dual agonist for hepatic and metabolic research.
Class
GLP-1/Glucagon dual agonist
Half-life
~5 days
Studied in
Hepatic lipid handling, energy expenditure, glycemic models.
What it is
Mazdutide (IBI362) is an oxyntomodulin-derived dual GLP-1/glucagon receptor agonist studied for combined incretin and hepatic metabolic effects.
Mechanism studied
Co-activation of GLP-1 and glucagon receptors for incretin/hepatic crosstalk.
Research notes
- Compared with tirzepatide and survodutide in dual/triple agonist research panels.
Before sourcing any material
- Confirm a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity).
- Check the stated peptide content per vial, not just the gross vial mass.
- Plan reconstitution volumes first so the vial size matches your protocol.
- Verify what is lawful in your jurisdiction — these are in-vitro research reagents, not medicines.