Research brief · Longevity
MOTS-c
Mitochondrial-derived peptide used in exercise-mimetic and AMPK research.
Class
Mitochondrial-derived peptide (16 aa)
Half-life
Short
Studied in
Metabolic flexibility, exercise mimetic studies.
What it is
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA region. Research describes AMPK activation and modulation of the folate/methionine cycle in exercise-mimetic models.
Mechanism studied
Activates AMPK and modulates folate/methionine cycle.
Research notes
- Encoded within mitochondrial DNA, distinguishing it from nuclear-encoded peptides.
Before sourcing any material
- Confirm a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity).
- Check the stated peptide content per vial, not just the gross vial mass.
- Plan reconstitution volumes first so the vial size matches your protocol.
- Verify what is lawful in your jurisdiction — these are in-vitro research reagents, not medicines.