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Protocols · Performance

ACE-031: literature-reported ranges

ACE-031 is a decoy receptor that binds myostatin and related ligands before they reach muscle. It reached phase 2 in Duchenne muscular dystrophy before the programme was halted over vascular safety signals — nosebleeds and telangiectasia — giving it an unusually well documented human record for a compound of this type.

Read this first

Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.

Compound at a glance

Class
Soluble activin receptor type IIB fused to an IgG1 Fc domain (myostatin trap)
Reported half-life
Long — the Fc fusion supports dosing measured in weeks
Routes used in the literature
Subcutaneous in registered trials
Also written as
Ramatercept, ActRIIB-Fc

What the published studies reported

Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.

Phase 1 healthy postmenopausal women

Reported quantity
0.02–3.0 mg/kg body weight as single administrations
Frequency
Single dose per cohort
Study duration
Followed for up to 4 months

Lean mass increases were reported at the higher cohorts alongside the first vascular signals.

Phase 2 Duchenne muscular dystrophy

Reported quantity
1 mg/kg and 3 mg/kg
Frequency
Once every 2 or 4 weeks
Study duration
Terminated early; up to 6 months planned

The trial was discontinued for safety, not for lack of an effect on muscle mass.

Mixed with 3 ml of bacteriostatic water

The same arithmetic for every vial size ACE-031 is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.

ACE-031 · 3 ml bacteriostatic water

Vial sizeConcentrationPer 1 unit
1 mg0.33 mg/ml3 mcg

No single reported amount applies to this compound, so only the concentration and the value of one unit are shown. Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.

Reconstitution maths

Supplied as a 1 mg lyophilised vial. In 3 ml of bacteriostatic water that gives 0.33 mg/ml, so one U-100 unit carries about 3.3 mcg.

Open the reconstitution calculator

How to read these figures

  • The development programme was stopped for safety reasons that were dose-related.
  • Epistaxis, gum bleeding and telangiectasia were the reported dose-limiting findings.
  • Myostatin inhibition affects more than skeletal muscle — activin signalling is systemic.

Sources and citations

No peer-reviewed primary literature reporting administered quantities exists for this item. Anything circulating online about quantities is anecdote rather than evidence, and this page will not reproduce it. The database links below are kept so you can check for yourself as new work is published.

Search the databases yourself

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© 2026 Peptide Intel Hub · Marbella · Educational research reference · For in-vitro research use only
Independent publication — we sell nothing. Supplier disclosure

Peptide Intel Hub is an independent educational publication. We are not affiliated with, owned by, or the same company as Regena Peptides and Regena.app (regena-peptides.com / regena.app). We do not sell, supply, ship or take payment for any compound. Because readers regularly ask where compounds discussed in published studies can be sourced for laboratory work, we list Regena Peptides and Regena.app as suppliers we have verified and trust — every batch is released with a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity). Outbound links are marked nofollow/sponsored and are provided to help readers, not to sell.