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Protocols · Performance

Dermorphin: literature-reported ranges

Dermorphin is a naturally occurring opioid peptide with very high mu-receptor affinity, studied in animal analgesia pharmacology since the 1980s. It is also a known doping agent in horse racing, which is where most contemporary references to it come from. There is no human therapeutic literature.

Read this first

Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.

Compound at a glance

Class
Heptapeptide opioid agonist originally isolated from Phyllomedusa frog skin
Reported half-life
Short; reported activity in animals substantially outlasts plasma presence
Routes used in the literature
Intracerebroventricular, intrathecal and systemic in animal pharmacology
Also written as

What the published studies reported

Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.

Rodent analgesia pharmacology

Reported quantity
Nanogram to low microgram quantities centrally; µg/kg systemically
Frequency
Single administration per experiment
Study duration
Acute observation windows

Potency figures are commonly quoted as several orders of magnitude above morphine on a molar basis.

Receptor binding assays

Reported quantity
Sub-nanomolar mu-opioid receptor affinity
Frequency
Single exposure
Study duration
Assay duration

Binding affinity is a laboratory property, not an administration figure.

Mixed with 3 ml of bacteriostatic water

The same arithmetic for every vial size Dermorphin is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.

Dermorphin · 3 ml bacteriostatic water

Vial sizeConcentrationPer 1 unit
5 mg1.67 mg/ml17 mcg
10 mg3.33 mg/ml33 mcg

No single reported amount applies to this compound, so only the concentration and the value of one unit are shown. Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.

Reconstitution maths

Supplied as 5 mg and 10 mg lyophilised vials. A 5 mg vial in 3 ml of bacteriostatic water gives 1.67 mg/ml.

Open the reconstitution calculator

How to read these figures

  • This is a potent opioid agonist; the class carries respiratory depression and dependence risk in every species studied.
  • It is a banned substance in human and equine sport and is screened for in doping panels.
  • No human clinical dataset exists to translate animal figures against.

Sources and citations

No peer-reviewed primary literature reporting administered quantities exists for this item. Anything circulating online about quantities is anecdote rather than evidence, and this page will not reproduce it. The database links below are kept so you can check for yourself as new work is published.

Search the databases yourself

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© 2026 Peptide Intel Hub · Marbella · Educational research reference · For in-vitro research use only
Independent publication — we sell nothing. Supplier disclosure

Peptide Intel Hub is an independent educational publication. We are not affiliated with, owned by, or the same company as Regena Peptides and Regena.app (regena-peptides.com / regena.app). We do not sell, supply, ship or take payment for any compound. Because readers regularly ask where compounds discussed in published studies can be sourced for laboratory work, we list Regena Peptides and Regena.app as suppliers we have verified and trust — every batch is released with a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity). Outbound links are marked nofollow/sponsored and are provided to help readers, not to sell.