Protocols · Longevity
Dosage and protocol information sourced exclusively from PeptideDosages.com.
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Dosage and protocol figures on this page are reproduced only from the matching PeptideDosages.com protocol. The 3 ml table is arithmetic based on those source amounts and the listed vial sizes. Educational research only — not instructions or medical advice.
The dosage amounts and schedules below come only from PeptideDosages.com. Syringe-unit figures are mathematical conversions of those source amounts using exactly 3 ml of bacteriostatic water. Educational reference only — not instructions or medical advice.
Glutathione · 600 mg Vial
Glutathione is dosed at 100 mg–200 mg daily via subcutaneous injection in educational protocols.
| Week | Daily Dose (mg) |
|---|---|
| Weeks 1–2 | 100 mg |
| Weeks 3–4 | 150 mg |
| Weeks 5–8 | 200 mg |
600 mg + 3 ml = 200.00 mg/ml. Choose your vial strength to update the units below.
| Source dose | U-100 syringe |
|---|---|
| 100 mg | 50 units |
| 150 mg | 75 units |
| 200 mg | 100 units |
Glutathione (GSH) is a tripeptide, meaning it is made of three amino acids. It is a major non-protein thiol found in nearly all eukaryotic cells and many prokaryotic cells, including plants (PMID 22303267, PMID 30427707). It exists in both reduced (GSH) and oxidized (GSSG) forms, with the reduced form predominant under normal conditions (PMID 35011559).
Glutathione acts as an essential non-enzymatic antioxidant, directly protecting cells from free radicals and pro-oxidants (PMID 36707132). It is a cofactor for antioxidant and detoxification enzymes such as glutathione peroxidases, glutathione S-transferases, and glyoxalases (PMID 36707132, PMID 36771108). Glutathione also regenerates vitamin E and helps detoxify electrophilic substances and xenobiotics (PMID 36707132). In cells, glutathione is involved in various processes, including protein folding, protecting protein thiols, cell cycle regulation, and apoptosis (PMID 36707132). It also plays a crucial role in the antioxidative system within peroxisomes (PMID 37804696) and mitochondria (PMID 28558477).
Glutathione synthesis occurs exclusively in the cytosol in animals and fungi, but it is transported to various subcellular compartments (PMID 30427707, PMID 36771108). Studies using genetically encoded fluorescent probes in cells have shown that glutathione pools in the mitochondrial matrix and intermembrane space are highly reduced, similar to the cytosolic pool (PMID 28558477). Impaired glutathione function in the brain is linked to neuronal loss during aging and in neurological diseases like Huntington's, Parkinson's, and Alzheimer's disease in animal models (PMID 35011559).
In humans, oral glutathione (250 mg once or twice daily, or 500 mg once daily) significantly reduced the melanin index compared to placebo in five randomized controlled trials and one open-arm clinical study (PMID 39444151). Topical glutathione 0.5% was more effective than 0.1% or placebo in human studies (PMID 39444151). A combination of topical 2% glutathione plus oral glutathione was superior to either treatment alone for skin lightening (PMID 39444151). Intravenous glutathione showed lack of efficacy and side effects in a human placebo-controlled study (PMID 39444151). The benefits of glutathione for skin lightening are considered moderate and unsustainable (PMID 39444151).
The exact mechanisms through which glutathione regulates brain metabolism are not fully understood (PMID 35011559). While glutathione transport is crucial, the molecular identity of many of its transporters remains unclear (PMID 30427707). Knowledge of glutathione redox homeostasis at the level of specific subcellular compartments is also limited, and the role of glutathione transport in this is largely unclear (PMID 30427707). Several human studies on glutathione for skin lightening had low or high risk of bias (PMID 39444151).
Summarised from the PubMed abstracts listed above. Educational reference only — not medical advice or instructions.
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