MGF is the IGF-1Ec splice variant expressed by skeletal muscle after mechanical loading or damage. The literature is largely molecular biology and rodent muscle work examining satellite cell activation; the human evidence base is observational expression data rather than administration studies.
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Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.
Compound at a glance
Class
Splice variant of IGF-1 produced by mechanically loaded muscle
Reported half-life
Minutes in circulation — the basis for the pegylated variant
Routes used in the literature
Intramuscular and local injection in animal studies
Also written as
Mechano Growth Factor, IGF-1Ec
What the published studies reported
Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.
Rodent muscle regeneration models
Reported quantity
Reported as local injections in the low microgram range per muscle
Frequency
Single or repeated local administration
Study duration
Days to a few weeks of observation
Effects reported are local to the injected muscle in most designs.
Cell-culture satellite cell assays
Reported quantity
Nanomolar peptide concentrations in medium
Frequency
Single exposure
Study duration
24–72 hours
Culture concentrations are not administration quantities.
Mixed with 3 ml of bacteriostatic water
The same arithmetic for every vial size MGF is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.
MGF · 3 ml bacteriostatic water
Vial size
Concentration
Per 1 unit
2 mg
0.67 mg/ml
7 mcg
No single reported amount applies to this compound, so only the concentration and the value of one unit are shown. Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.
Reconstitution maths
Supplied as a 2 mg lyophilised vial. In 3 ml of bacteriostatic water that gives 0.67 mg/ml, so one U-100 unit carries about 6.7 mcg.
Very rapid clearance means unmodified MGF has minimal systemic exposure.
Human administration studies do not exist; expression data is not dosing data.
IGF pathway agonists carry theoretical proliferative concerns that the literature flags repeatedly.
Sources and citations
No peer-reviewed primary literature reporting administered quantities exists for this item. Anything circulating online about quantities is anecdote rather than evidence, and this page will not reproduce it. The database links below are kept so you can check for yourself as new work is published.
Peptide Intel Hub is an independent publication and has no affiliation, ownership or commercial relationship with the suppliers listed. We sell nothing and take no payments — links are editorial references only.
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Peptide Intel Hub is an independent educational publication. We are not affiliated with, owned by, or the same company as Regena Peptides and Regena.app (regena-peptides.com / regena.app). We do not sell, supply, ship or take payment for any compound. Because readers regularly ask where compounds discussed in published studies can be sourced for laboratory work, we list Regena Peptides and Regena.app as suppliers we have verified and trust — every batch is released with a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity). Outbound links are marked nofollow/sponsored and are provided to help readers, not to sell.