PEG-MGF is MGF with a polyethylene glycol chain attached to slow renal clearance. The rationale is pharmacokinetic rather than pharmacodynamic — the peptide sequence is the same, the exposure window is longer. The published record is thin and almost entirely preclinical.
Read this first
Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.
Compound at a glance
Class
Polyethylene-glycol conjugated MGF analogue
Reported half-life
Extended relative to MGF; pegylation is used specifically to slow clearance
Routes used in the literature
Subcutaneous and intramuscular in the animal record
Also written as
Pegylated Mechano Growth Factor
What the published studies reported
Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.
Rodent muscle studies
Reported quantity
Low microgram to low milligram per kilogram, depending on the paper
Frequency
Two to three times weekly in most designs
Study duration
2–6 weeks
Fewer administrations than unmodified MGF is the stated purpose of pegylation.
Mixed with 3 ml of bacteriostatic water
The same arithmetic for every vial size PEG-MGF is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.
PEG-MGF · 3 ml bacteriostatic water
Vial size
Concentration
Per 1 unit
2 mg
0.67 mg/ml
7 mcg
No single reported amount applies to this compound, so only the concentration and the value of one unit are shown. Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.
Reconstitution maths
Supplied as a 2 mg lyophilised vial. In 3 ml of bacteriostatic water that gives 0.67 mg/ml, so one U-100 unit carries about 6.7 mcg.
Pegylation changes clearance, not the underlying IGF-pathway questions.
Published data is sparse and largely non-peer-reviewed outside of a small preclinical set.
No human pharmacokinetic study has been published.
Sources and citations
No peer-reviewed primary literature reporting administered quantities exists for this item. Anything circulating online about quantities is anecdote rather than evidence, and this page will not reproduce it. The database links below are kept so you can check for yourself as new work is published.
Peptide Intel Hub is an independent publication and has no affiliation, ownership or commercial relationship with the suppliers listed. We sell nothing and take no payments — links are editorial references only.
Share
Independent publication — we sell nothing. Supplier disclosure
Peptide Intel Hub is an independent educational publication. We are not affiliated with, owned by, or the same company as Regena Peptides and Regena.app (regena-peptides.com / regena.app). We do not sell, supply, ship or take payment for any compound. Because readers regularly ask where compounds discussed in published studies can be sourced for laboratory work, we list Regena Peptides and Regena.app as suppliers we have verified and trust — every batch is released with a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity). Outbound links are marked nofollow/sponsored and are provided to help readers, not to sell.