Survodutide is an investigational dual glucagon/GLP-1 receptor agonist studied in obesity, type 2 diabetes and metabolic dysfunction-associated steatohepatitis. Unlike most compounds on this site it has a substantial registered human trial record, so the reported figures come from phase 2 protocols rather than animal work.
Read this first
Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.
Compound at a glance
Class
Dual glucagon receptor / GLP-1 receptor agonist
Reported half-life
Approximately 6 days in published human pharmacokinetics
Routes used in the literature
Subcutaneous in registered trials
Also written as
BI 456906
What the published studies reported
Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.
Phase 2 obesity trial escalation
Reported quantity
0.6 mg escalating to 3.6, 4.8 or 6.0 mg weekly maintenance
Frequency
Once weekly
Study duration
20-week escalation, 46-week total in the reported protocol
Escalation was stepwise; the trial reported gastrointestinal effects as the dominant tolerability limit.
Phase 2 MASH trial
Reported quantity
2.4, 4.8 and 6.0 mg maintenance arms
Frequency
Once weekly
Study duration
48 weeks
Histological improvement was the reported endpoint across the three maintenance arms.
Mixed with 3 ml of bacteriostatic water
The same arithmetic for every vial size Survodutide is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.
Survodutide · 3 ml bacteriostatic water
Vial size
Concentration
Per 1 unit
2 mg
0.67 mg/ml
7 mcg
5 mg
1.67 mg/ml
17 mcg
10 mg
3.33 mg/ml
33 mcg
No single reported amount applies to this compound, so only the concentration and the value of one unit are shown. Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.
Reconstitution maths
Supplied as 2 mg, 5 mg and 10 mg lyophilised vials. A 5 mg vial in 3 ml of bacteriostatic water gives 1.67 mg/ml, so one U-100 unit carries 16.7 mcg.
Trial figures follow a fixed escalation schedule — the maintenance number is not a starting number.
The glucagon arm of the mechanism distinguishes this compound from single incretin agonists.
This is an investigational compound; it has no marketing authorisation.
Sources and citations
No peer-reviewed primary literature reporting administered quantities exists for this item. Anything circulating online about quantities is anecdote rather than evidence, and this page will not reproduce it. The database links below are kept so you can check for yourself as new work is published.
Peptide Intel Hub is an independent publication and has no affiliation, ownership or commercial relationship with the suppliers listed. We sell nothing and take no payments — links are editorial references only.
Share
Independent publication — we sell nothing. Supplier disclosure
Peptide Intel Hub is an independent educational publication. We are not affiliated with, owned by, or the same company as Regena Peptides and Regena.app (regena-peptides.com / regena.app). We do not sell, supply, ship or take payment for any compound. Because readers regularly ask where compounds discussed in published studies can be sourced for laboratory work, we list Regena Peptides and Regena.app as suppliers we have verified and trust — every batch is released with a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity). Outbound links are marked nofollow/sponsored and are provided to help readers, not to sell.