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Protocols · Growth Hormone

IGF-DES: literature-reported ranges

DES(1-3) IGF-1 lacks the first three amino acids of native IGF-1, which sharply reduces binding to IGF binding proteins and makes it substantially more potent in cell assays. Its very short half-life is the defining pharmacokinetic feature and the reason it is studied locally rather than systemically.

Read this first

Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.

Compound at a glance

Class
Truncated IGF-1 analogue missing the first three N-terminal residues
Reported half-life
Very short — reported in minutes, far shorter than IGF-1 LR3
Routes used in the literature
Subcutaneous and local injection in animal work
Also written as
DES(1-3) IGF-1

What the published studies reported

Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.

Cell-culture potency assays

Reported quantity
Reported as roughly 10-fold more potent than IGF-1 at equal concentration
Frequency
Single exposure
Study duration
Assay duration

Potency here reflects reduced binding-protein sequestration, not a different receptor.

Rodent growth and muscle studies

Reported quantity
Microgram-per-kilogram quantities
Frequency
Once daily or per experiment
Study duration
Days to weeks

Figures are per kilogram of animal body weight.

Mixed with 3 ml of bacteriostatic water

The same arithmetic for every vial size IGF-DES is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.

IGF-DES · 3 ml bacteriostatic water

Vial sizeConcentrationPer 1 unit
2 mg0.67 mg/ml7 mcg

No single reported amount applies to this compound, so only the concentration and the value of one unit are shown. Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.

Reconstitution maths

Supplied as a 2 mg lyophilised vial. In 3 ml of bacteriostatic water that gives 0.67 mg/ml, so one U-100 unit carries about 6.7 mcg.

Open the reconstitution calculator

How to read these figures

  • Minutes-long half-life makes systemic exposure minimal compared with IGF-1 LR3.
  • IGF pathway agonists raise proliferative and hypoglycaemia concerns throughout the literature.
  • No human administration study has been published.

Sources and citations

No peer-reviewed primary literature reporting administered quantities exists for this item. Anything circulating online about quantities is anecdote rather than evidence, and this page will not reproduce it. The database links below are kept so you can check for yourself as new work is published.

Search the databases yourself

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© 2026 Peptide Intel Hub · Marbella · Educational research reference · For in-vitro research use only
Independent publication — we sell nothing. Supplier disclosure

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