Kisspeptin-10 — Literature-Reported Ranges & Study Protocols

Read this first

Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.

Compound at a glance

Class: Decapeptide KISS1R agonist
Reported half-life: Approximately 4 minutes
Routes used in the literature: Intravenous bolus and infusion in the published human studies
Also written as: —

What the published studies reported

Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.

Human intravenous bolus studies

Reported quantity: 0.3–10 nmol/kg
Frequency: Single bolus
Study duration: LH sampling over 4–6 hours

LH pulse generation is the primary measured readout.

Human infusion studies

Reported quantity: 0.1–1.0 nmol/kg/hour
Frequency: Continuous infusion
Study duration: Up to 8–24 hours

Prolonged infusion is used to probe desensitisation of the axis.

Dosage chart

These figures match the published chart for this compound on peptidedosages.com, including the reconstitution volume, resulting concentration, insulin-syringe units and the staged schedule. Educational reference only — not instructions, and not medical advice.

Kisspeptin-10 · 10 mg Vial

Kisspeptin is dosed at 100 mcg–200 mcg daily via subcutaneous injection in educational protocols. A 10 mg vial reconstituted with bacteriostatic water yields about 3.33 mg/mL. This information is for research and educational use only.

Reconstitute: Add 3.0 mL bacteriostatic water → ~ 3.33 mg/mL concentration.
Typical daily range: 100–200 mcg once daily (gradual titration).
Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U‑100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.

Standard / Gradual Approach (3 mL = ~3.33 mg/mL)

Week	Daily Dose (mcg)	Units (per injection) (mL)
Weeks 1–2	100 mcg	3 units (0.03 mL)
Weeks 3–8 (or 3–12)	200 mcg	6 units (0.06 mL)

Source chart on peptidedosages.com

Mixed with 3 ml of bacteriostatic water

The same arithmetic for every vial size Kisspeptin-10 is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.

Kisspeptin-10 · 3 ml bacteriostatic water

Vial size	Concentration	Per 1 unit	100 mcg =	200 mcg =
5 mg	1.67 mg/ml	17 mcg	6.0 units	12 units
10 mg	3.33 mg/ml	33 mcg	3.0 units	6.0 units

Unit columns use the range reported for this compound (100 mcg–200 mcg). Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.

Reconstitution maths

Figures in this literature are molar, not mass-based. Kisspeptin-10 is roughly 1302 g/mol, so 1 nmol is about 1.3 µg — conversion is essential before comparing to any mass-labelled vial.

Open the reconstitution calculator

How to read these figures

Nanomole-per-kilogram units make this the easiest compound here to misread by a factor of a thousand.
The extremely short half-life is why every human protocol uses bolus or infusion, not subcutaneous administration.
Kisspeptin-10 and kisspeptin-54 have different potency and duration.

Sources and citations

These are the published records the figures on this page are drawn from. Each one describes what researchers administered, in which model or population, and over what period. Quantities reported in a study are specific to that study's design and are not transferable guidance.

[1]
The effects of kisspeptin-10 on reproductive hormone release show sexual dimorphism in humans
Jayasena CN, Nijher GMK, Comninos AN, et al. · Journal of Clinical Endocrinology & Metabolism · 2011 · PMID 21976724
Healthy men and women received intravenous kisspeptin-10 boluses (up to 3.2 nmol/kg) to assess LH, FSH, and testosterone/estradiol responses.
View the record
[2]
Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men
George JT, Veldhuis JD, Roseweir AK, et al. · Journal of Clinical Endocrinology & Metabolism · 2011 · PMID 21632807
Healthy men received continuous intravenous kisspeptin-10 infusion (4 microgram/kg/h) for 22.5 hours to assess LH pulsatility.
View the record
[3]
Direct comparison of the effects of intravenous kisspeptin-10, kisspeptin-54 and GnRH on gonadotrophin secretion in healthy men
Jayasena CN, Abbara A, Narayanaswamy S, et al. · Human Reproduction · 2015 · DOI 10.1093/humrep/dev143
Healthy men received intravenous boluses of kisspeptin-10 compared with kisspeptin-54 and GnRH to compare gonadotropin secretion responses.
View the record

Search the databases yourself

Read the Kisspeptin-10 research brief

Other hormone compounds

HCGGlycoprotein hormone, LH-receptor agonist OxytocinNonapeptide hormone

All research protocols

Peptide Intel Hub is an independent publication and has no affiliation, ownership or commercial relationship with the suppliers listed. We sell nothing and take no payments — links are editorial references only.