Protocols · Hormone
Dosage and protocol information sourced exclusively from PeptideDosages.com.
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Dosage and protocol figures on this page are reproduced only from the matching PeptideDosages.com protocol. The 3 ml table is arithmetic based on those source amounts and the listed vial sizes. Educational research only — not instructions or medical advice.
The dosage amounts and schedules below come only from PeptideDosages.com. Syringe-unit figures are mathematical conversions of those source amounts using exactly 3 ml of bacteriostatic water. Educational reference only — not instructions or medical advice.
Kisspeptin-10 · 10 mg Vial
Kisspeptin is dosed at 100 mcg–200 mcg daily via subcutaneous injection in educational protocols.
| Week | Daily Dose (mcg) |
|---|---|
| Weeks 1–2 | 100 mcg |
| Weeks 3–8 (or 3–12) | 200 mcg |
5 mg + 3 ml = 1.67 mg/ml. Choose your vial strength to update the units below.
| Source dose | U-100 syringe |
|---|---|
| 100 mcg | 6.0 units |
| 200 mcg | 12 units |
Kisspeptin-10 (Kp-10) is a peptide hormone, a minimal biologically active fragment of kisspeptin, which is encoded by the Kiss1 gene (PMID 39775975, PMID 28692647). It plays a crucial role in reproduction and is known to increase circulating follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels in humans (PMID 38978171).
Kisspeptin-10 exerts its effects by binding to its receptor, G-protein-coupled receptor 54 (GPR54) (PMID 39775975, PMID 29391507, PMID 38346942). In osteoclasts, Kp-10 binding to GPR54 activates Dusp18, which then dephosphorylates Src at Tyr 416, thereby preventing bone loss (PMID 38346942, animal study). This system also influences osteoblast differentiation by regulating BMP2 expression and activation via GPR54-mediated NFATc4 signaling (PMID 29391507, cell study).
In female mice fed a high-fat diet, kisspeptin-10 administration for 21 days decreased body weight, blood glucose, and energy intake, while restoring ileal villi length and increasing proportions of GIP and GLP-1 positive cells (PMID 41301510, animal study). It also enhanced circulating FSH and LH concentrations in these mice (PMID 41301510, animal study). Furthermore, Kp-10 increased beta-cell proliferation and normalized glucagon radius in pancreatic islets (PMID 41301510, animal study). In rats, Kp-10 altered myocardial cell morphology, serum metabolite levels, and gene/protein expression related to heart diseases, indicating profound effects on cardiac tissue (PMID 28692647, animal study). Kisspeptin-10 can also increase neuropeptide Y (NPY) gene expression and decrease brain-derived neurotrophic factor (BDNF) in rat hypothalamic cells, suggesting a potential orexigenic (appetite-stimulating) effect (PMID 30477219, cell study). Kisspeptin-10 concentrations fluctuate during pregnancy in dairy cows, alongside gonadotropin inhibiting hormone (GnIH), suggesting a role in maintaining endocrine balance during gestation (PMID 36398669, animal study).
Kisspeptin-10 is known to increase circulating follicle-stimulating hormone, luteinizing hormone, and testosterone levels in humans (PMID 38978171). Due to its testosterone-increasing effect, it is included in the 2024 World Anti-Doping Agency Prohibited List (PMID 38978171).
Kisspeptin-10 is rapidly eliminated, with a reported elimination time of 30 minutes after injection in rats (PMID 38978171, animal study). Metabolism studies in human serum identified four peptide fragments (y9, y8, y7, y5) (PMID 38978171, cell study). Further research is needed to understand the kinetics of a degradation product likely caused by tryptophan residue oxidation (PMID 38978171). The full extent of its metabolic effects and mechanisms, beyond reproduction, is still being explored (PMID 41301510).
Summarised from the PubMed abstracts listed above. Educational reference only — not medical advice or instructions.
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