Rodent cognitive-deficit models
- Reported quantity
- Reported active from around 0.05 mg/kg orally, commonly 1–2 mg/kg
- Frequency
- Once daily
- Study duration
- 5–14 days
Morris water-maze performance in scopolamine-impaired rats is the classic readout.
Protocols · Cognitive
Dihexa: literature-reported ranges
Dihexa was developed at Washington State University as an orally active angiotensin IV analogue that potentiates hepatocyte growth factor signalling. The record is rodent cognition models and in-vitro synaptogenesis; there is no human data.
Read this first
Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.
Compound at a glance
- Class
- Angiotensin IV analogue, HGF/c-Met potentiator
- Reported half-life
- Engineered for metabolic stability and oral availability in rodents
- Routes used in the literature
- Oral and intraperitoneal in the published rodent work
- Also written as
- N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
What the published studies reported
Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.
In-vitro synaptogenesis assays
- Reported quantity
- Femtomolar to picomolar activity reported
- Frequency
- Single exposure
- Study duration
- Days in culture
The reported potency here is extraordinary and has had limited independent replication.
Reconstitution maths
Not water soluble in the way a peptide is — published work uses DMSO or oil vehicles, and this is a frequent source of failed preparations.
Open the reconstitution calculatorHow to read these figures
- HGF/c-Met potentiation is a growth-factor pathway with recognised oncology implications.
- No human pharmacokinetic or safety data of any kind has been published.
- The headline potency figures come from a small number of related publications.
Sources and citations
These are the published records the figures on this page are drawn from. Each one describes what researchers administered, in which model or population, and over what period. Quantities reported in a study are specific to that study's design and are not transferable guidance.
- [1]Evaluation of Metabolically Stabilized Angiotensin IV Analogs as Procognitive/Antidementia Agents
McCoy AT, Benoist CC, Wright JW, Kawas LH, et al. · J Pharmacol Exp Ther · 2012 · DOI 10.1124/jpet.112.199497
Aged and scopolamine-impaired rats received oral or intraperitoneal dihexa at nanomolar-to-microgram/kg doses over a period of days, and performance on spatial learning/memory tasks was measured.
View the record
Search the databases yourself
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All research protocolsPeptide Intel Hub is an independent publication and has no affiliation, ownership or commercial relationship with the suppliers listed. We sell nothing and take no payments — links are editorial references only.