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Protocols · Longevity

Epithalon: literature-reported ranges

Epithalon's literature is almost entirely Russian, spanning rodent lifespan studies and long-running human observational cohorts from the St Petersburg Institute of Bioregulation. Independent Western replication is thin, which is the single most important caveat when reading any figure below.

Read this first

Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.

Compound at a glance

Class
Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
Reported half-life
Minutes in plasma
Routes used in the literature
Intramuscular and intranasal in the published Russian literature
Also written as
Epitalon

What the published studies reported

Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.

Russian human observational cohorts

Reported quantity
5–10 mg per administration
Frequency
Once daily
Study duration
10-day courses, repeated a few times per year in the cohort protocols

The 10-day course structure, not a continuous schedule, is what the published cohorts actually used.

Rodent lifespan studies

Reported quantity
0.1–1.0 µg per animal
Frequency
5 consecutive days per month
Study duration
Continued across the animal's lifespan

Telomerase activity and tumour incidence were the primary reported endpoints.

Dosage chart

These figures match the published chart for this compound on peptidedosages.com, including the reconstitution volume, resulting concentration, insulin-syringe units and the staged schedule. Educational reference only — not instructions, and not medical advice.

Epitalon / Epithalon · 10 mg Vial

Epitalon is dosed at 5 mg daily via subcutaneous injection in educational protocols. A Epithalon reconstituted with bacteriostatic water yields about 5 mg/mL. This information is for research and educational use only.

Reconstitute
Add 2.0 mL bacteriostatic water → 5 mg/mL concentration.
Typical daily dose
5,000 mcg (5 mg) once daily for 20 consecutive days.
Easy measuring
At 5 mg/mL, 1 unit = 0.01 mL = 50 mcg on a U-100 insulin syringe.
Storage
Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.

Standard Protocol (2 mL = 5 mg/mL)

PhaseDaily Dose (mcg)Units (per injection) (mL)
Days 1–20 (Cycle On)5,000 mcg (5 mg)100 units (1.00 mL)
Weeks 4–26 (Cycle Off)0 mcg
Source chart on peptidedosages.com

Mixed with 3 ml of bacteriostatic water

The same arithmetic for every vial size Epithalon is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.

Epithalon · 3 ml bacteriostatic water

Vial sizeConcentrationPer 1 unit5 mg =
10 mg3.33 mg/ml33 mcg150 units
50 mg16.67 mg/ml167 mcg30 units

Unit columns use the range reported for this compound (5 mg). Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.

Reconstitution maths

A 10 mg vial in 2 mL of bacteriostatic water gives 5 mg/mL; 0.2 mL draws 1 mg.

Open the reconstitution calculator

How to read these figures

  • Publication quality in this literature is materially below the standard of the incretin or tesamorelin datasets.
  • Telomerase claims rest on a small number of in-vitro measurements.
  • 'Epitalon' and 'Epithalon' are the same tetrapeptide under different transliterations.

Sources and citations

These are the published records the figures on this page are drawn from. Each one describes what researchers administered, in which model or population, and over what period. Quantities reported in a study are specific to that study's design and are not transferable guidance.

  1. [1]
    Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-Up

    Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA · Bull Exp Biol Med · 2011 · URL khavinson.info/assets/files/2011-Korkushko.pdf

    Elderly subjects with accelerated aging received a defined course of injections of pineal/pituitary peptide preparations (including epithalamin, precursor to synthetic epitalon) repeated periodically over a 15-year follow-up, assessing effects on mortality and aging markers.

    View the record
  2. [2]
    Geroprotective Effect of Epithalamine (Pineal Gland Peptide Preparation) in Elderly Subjects with Accelerated Aging

    Korkushko OV, Khavinson VKh, Shatilo VB, Antoniuk-Shcheglova IA · Bull Exp Biol Med · 2006 · URL khavinson.info/downloads/2006-Korkushko.pdf

    Elderly subjects received a course of intramuscular epithalamine injections (10 mg/day for 10-20 days per course) to evaluate geroprotective effects on melatonin rhythm and functional aging markers.

    View the record
  3. [3]
    Peptides of pineal gland and thymus prolong human life

    Khavinson VKh, Morozov VG · Neuro Endocrinol Lett · 2003 · URL khavinson.info/assets/files/skan/2003-khavinson_morozov1.pdf

    Long-term cohort study in which elderly subjects received repeated courses of pineal and thymic peptide preparations (precursors to synthetic peptides such as epitalon), evaluating effects on mortality rates over years of follow-up.

    View the record

Search the databases yourself

Read the Epithalon research brief

Other longevity compounds

All research protocols

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© 2026 Peptide Intel Hub · Marbella · Educational research reference · For in-vitro research use only
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