Epithalon's literature is almost entirely Russian, spanning rodent lifespan studies and long-running human observational cohorts from the St Petersburg Institute of Bioregulation. Independent Western replication is thin, which is the single most important caveat when reading any figure below.
Read this first
Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.
Compound at a glance
Class
Synthetic tetrapeptide (Ala-Glu-Asp-Gly)
Reported half-life
Minutes in plasma
Routes used in the literature
Intramuscular and intranasal in the published Russian literature
Also written as
Epitalon
What the published studies reported
Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.
Russian human observational cohorts
Reported quantity
5–10 mg per administration
Frequency
Once daily
Study duration
10-day courses, repeated a few times per year in the cohort protocols
The 10-day course structure, not a continuous schedule, is what the published cohorts actually used.
Rodent lifespan studies
Reported quantity
0.1–1.0 µg per animal
Frequency
5 consecutive days per month
Study duration
Continued across the animal's lifespan
Telomerase activity and tumour incidence were the primary reported endpoints.
Dosage chart
These figures match the published chart for this compound on peptidedosages.com, including the reconstitution volume, resulting concentration, insulin-syringe units and the staged schedule. Educational reference only — not instructions, and not medical advice.
Epitalon / Epithalon · 10 mg Vial
Epitalon is dosed at 5 mg daily via subcutaneous injection in educational protocols. A Epithalon reconstituted with bacteriostatic water yields about 5 mg/mL. This information is for research and educational use only.
Reconstitute
Add 2.0 mL bacteriostatic water → 5 mg/mL concentration.
Typical daily dose
5,000 mcg (5 mg) once daily for 20 consecutive days.
Easy measuring
At 5 mg/mL, 1 unit = 0.01 mL = 50 mcg on a U-100 insulin syringe.
Storage
Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles.
The same arithmetic for every vial size Epithalon is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.
Epithalon · 3 ml bacteriostatic water
Vial size
Concentration
Per 1 unit
5 mg =
10 mg
3.33 mg/ml
33 mcg
150 units
50 mg
16.67 mg/ml
167 mcg
30 units
Unit columns use the range reported for this compound (5 mg). Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.
Reconstitution maths
A 10 mg vial in 2 mL of bacteriostatic water gives 5 mg/mL; 0.2 mL draws 1 mg.
Publication quality in this literature is materially below the standard of the incretin or tesamorelin datasets.
Telomerase claims rest on a small number of in-vitro measurements.
'Epitalon' and 'Epithalon' are the same tetrapeptide under different transliterations.
Sources and citations
These are the published records the figures on this page are drawn from. Each one describes what researchers administered, in which model or population, and over what period. Quantities reported in a study are specific to that study's design and are not transferable guidance.
[1]
Peptide Geroprotector from the Pituitary Gland Inhibits Rapid Aging of Elderly People: Results of 15-Year Follow-Up
Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA · Bull Exp Biol Med · 2011 · URL khavinson.info/assets/files/2011-Korkushko.pdf
Elderly subjects with accelerated aging received a defined course of injections of pineal/pituitary peptide preparations (including epithalamin, precursor to synthetic epitalon) repeated periodically over a 15-year follow-up, assessing effects on mortality and aging markers.
Geroprotective Effect of Epithalamine (Pineal Gland Peptide Preparation) in Elderly Subjects with Accelerated Aging
Korkushko OV, Khavinson VKh, Shatilo VB, Antoniuk-Shcheglova IA · Bull Exp Biol Med · 2006 · URL khavinson.info/downloads/2006-Korkushko.pdf
Elderly subjects received a course of intramuscular epithalamine injections (10 mg/day for 10-20 days per course) to evaluate geroprotective effects on melatonin rhythm and functional aging markers.
Long-term cohort study in which elderly subjects received repeated courses of pineal and thymic peptide preparations (precursors to synthetic peptides such as epitalon), evaluating effects on mortality rates over years of follow-up.
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Peptide Intel Hub is an independent educational publication. We are not affiliated with, owned by, or the same company as Regena Peptides and Regena.app (regena-peptides.com / regena.app). We do not sell, supply, ship or take payment for any compound. Because readers regularly ask where compounds discussed in published studies can be sourced for laboratory work, we list Regena Peptides and Regena.app as suppliers we have verified and trust — every batch is released with a lot-matched third-party certificate of analysis (HPLC purity and mass-spectrometry identity). Outbound links are marked nofollow/sponsored and are provided to help readers, not to sell.