Cancer cell-line assays
- Reported quantity
- Typically 20–200 µmol/L in culture medium
- Frequency
- Single exposure per assay
- Study duration
- 1–48 hours of observation
Culture concentrations do not translate into an administered quantity.
Protocols · Regenerative
PNC-27: literature-reported ranges
PNC-27 is a laboratory peptide built from a p53 fragment joined to a penetratin-style leader. Published work is dominated by cell-culture assays reporting selective membrane disruption of cancer cell lines. There is no human trial record of any kind.
Read this first
Every figure on this page is a range reported in published literature or in a publicly documented study protocol. It is a record of what researchers used, not a recommendation, a therapeutic protocol, or advice. Peptide Intel Hub is an independent publication, sells nothing, and describes these compounds as in-vitro research reagents only.
Compound at a glance
- Class
- p53-derived peptide fused to a membrane-penetrating leader sequence
- Reported half-life
- Not characterised in vivo; almost all work is cell-culture based
- Routes used in the literature
- In-vitro exposure; intraperitoneal in the small animal record
- Also written as
- —
What the published studies reported
Each row below describes one body of work. The model and population are part of the figure — a rodent per-kilogram quantity and a human trial quantity are not comparable.
Mouse xenograft models
- Reported quantity
- Reported in the low mg/kg range intraperitoneally
- Frequency
- Daily or several times weekly depending on the model
- Study duration
- 2–4 weeks
The in-vivo record is small and the models differ substantially between papers.
Mixed with 3 ml of bacteriostatic water
The same arithmetic for every vial size PNC-27 is supplied in, using a fixed 3 ml of bacteriostatic water. One unit on a U-100 insulin syringe is 0.01 ml, so the unit column below is simply the volume that carries the reported amount. Educational arithmetic only — not instructions, and not medical advice.
PNC-27 · 3 ml bacteriostatic water
| Vial size | Concentration | Per 1 unit |
|---|---|---|
| 5 mg | 1.67 mg/ml | 17 mcg |
| 10 mg | 3.33 mg/ml | 33 mcg |
No single reported amount applies to this compound, so only the concentration and the value of one unit are shown. Only the vial sizes this compound is actually supplied in are shown, and every figure assumes exactly 3 ml of bacteriostatic water. For any other volume, use the reconstitution calculator.
Reconstitution maths
Supplied as 5 mg and 10 mg lyophilised vials. A 10 mg vial in 3 ml of bacteriostatic water gives 3.33 mg/ml.
Open the reconstitution calculatorHow to read these figures
- This is a research reagent with no clinical evidence base whatsoever.
- Membrane-disruption mechanisms are not inherently selective outside controlled assay conditions.
- Micromolar culture figures are frequently misquoted online as if they were doses.
Sources and citations
No peer-reviewed primary literature reporting administered quantities exists for this item. Anything circulating online about quantities is anecdote rather than evidence, and this page will not reproduce it. The database links below are kept so you can check for yourself as new work is published.
Search the databases yourself
Other regenerative compounds
ARA-29011-amino-acid erythropoietin helix-B fragmentBPC-157Synthetic pentadecapeptide (gastric origin)BPC-157 + TB-500Pentadecapeptide + actin-sequestering fragment blendGHK-CuCopper-binding tripeptide
All research protocolsPeptide Intel Hub is an independent publication and has no affiliation, ownership or commercial relationship with the suppliers listed. We sell nothing and take no payments — links are editorial references only.