Protocols · Cognitive
Dosage and protocol information sourced exclusively from PeptideDosages.com.
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Dosage and protocol figures on this page are reproduced only from the matching PeptideDosages.com protocol. The 3 ml table is arithmetic based on those source amounts and the listed vial sizes. Educational research only — not instructions or medical advice.
The dosage amounts and schedules below come only from PeptideDosages.com. Syringe-unit figures are mathematical conversions of those source amounts using exactly 3 ml of bacteriostatic water. Educational reference only — not instructions or medical advice.
Cortagen · 20 mg Vial
Cortagen is dosed at 1 mg–2 mg daily via subcutaneous injection in educational protocols.
| Week | Daily Dose (mcg) |
|---|---|
| Weeks 1–2 | 1000 mcg |
| Weeks 3–4 | 2000 mcg |
20 mg + 3 ml = 6.67 mg/ml. Choose your vial strength to update the units below.
| Source dose | U-100 syringe |
|---|---|
| 1000 mcg | 15 units |
| 2000 mcg | 30 units |
Cortagen is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Pro (PMID 11713572). It was developed through directed synthesis based on the amino acid analysis of Cortexin, a natural brain cortex peptide preparation (PMID 15159690).
Cortagen is considered a 'peptide bioregulator' (PMID 37042594). In aging individuals (75-88 years old), it has been observed to induce deheterochromatinization (unrolling or decondensation) of total heterochromatin and satellite stalks of acrocentric chromosomes in lymphocytes, activating ribosomal gene synthetic processes (PMID 37042594, PMID 33526740). This process, termed remodeling of facultative heterochromatin, suggests that Cortagen can selectively deheterochromatinize specific chromosomal regions, potentially releasing inactive genes (PMID 33526740).
Cortagen has also been shown to influence gene expression. In mouse heart tissue, injections of Cortagen for five days altered the expression of 234 clones, matching 110 known genes across various functional categories (animal study) (PMID 15159690).
Cortagen stimulated the growth of explants from rat brain cortex in organotypic cultures, demonstrating a tissue-specific effect (animal study) (PMID 11713572). It activated interleukin-2 (IL-2) mRNA synthesis in splenocytes from CBA mice in vitro, though its effect was less pronounced compared to other peptides like Vilon and Epithalon (cell study) (PMID 12447482).
In rats, injections of Cortagen decreased the content of lipid peroxidation products and reduced oxidative modification of proteins in serum and cerebral cortex. This was accompanied by a suppression of antioxidant activity (animal study) (PMID 18239817). Cortagen also prevented excessive activation of lipid peroxidation and a decrease in antioxidant activity in brain tissues of rats with chronic brain ischemia, accelerating recovery of disturbed individual behavior (animal study) (PMID 21476278).
In humans, Cortagen demonstrated a therapeutic effect on the structural and functional recovery of peripheral nerve tissue after trauma (human study) (PMID 15159690). Other effects on cardiovascular and cerebrovascular parameters were also observed (human study) (PMID 15159690).
Studies using lymphocytes from individuals aged 75-88 years showed that Cortagen induced deheterochromatinization, indicating a potential role in modifying chromatin structure associated with aging (cell study) (PMID 37042594, PMID 33526740).
Heterochromatin: Densely packed DNA within chromosomes. 'Condensed' or 'heterochromatinized' means the DNA is tightly wound, which can silence genes (PMID 37042594).
Deheterochromatinization: The process of 'unrolling' or 'decondensing' heterochromatin, potentially making genes available for expression (PMID 37042594).
Interleukin-2 (IL-2): A cytokine that plays a key role in the immune system (PMID 12447482).
Lipid peroxidation (LPO): A process where free radicals damage lipids, indicating oxidative stress (PMID 18239817).
Summarised from the PubMed abstracts listed above. Educational reference only — not medical advice or instructions.
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